复旦大学基础医学院研究生导师简介-孙宁研究员

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　　姓名：孙宁 博士
　　职称：研究员
　　E-MAIL: sunning@fudan.edu.cn
　　WWW: http://homepage.fudan.edu.cn/sunning
　　研究方向
　　1.分子心脏医学和心血管疾病机制
　　2.多能干细胞生物学
　　3.中西结合的基础与转化医学研究
　　4.中医基础理论的现代化机制阐释
　　重要学术贡献
　　建立了脂肪干细胞重编程为诱导多能干细胞的新方;建立了小动物活体生物荧光影像追踪移植干细胞的新技术;首次建立了人类家族遗传性扩张型心肌病诱导多能干细胞的模型并进行了疾病新机制的研究;建立了人类诱导多能干细胞分化来源的心室肌细胞的纯化新技术并制备了可用于移植的人造人类心室肌组织等。
　　荣誉与获奖
　　2013 中组部第四批“青年千人”
　　2014 国家自然科学基金“优秀青年科学基金”
　　2017 上海市“优秀学术带头人计划”
　　国内外学术团体任职
　　(1)中国病理生理学会理事
　　(2)中国生理学会理事
　　(3)上海市病理生理学会理事
　　(4)安徽省干细胞临床研究专家委员会特邀顾问
　　(5)微循环杂志编委
　　受邀审稿学术刊物
　　2010-今 Journal of Amrerican College of Cardiology
　　2011-今 Stem Cell and Development
　　2017-今 Protein Cell
　　校内学术机构任职(复旦大学)
　　基础医学院伦理委员会/委员
　　基础医学院技术平台委员会/委员
　　受邀学术报告 (近5年国内大会报告、国际重要会议专题报告以上)
　　发表论文
　　1.Zhan Y, Sun X, Li B, Cai H, Xu C, Liang Q, Lu C, Qian R, Chen S, Yin L, Sheng W, Huang G, Sun A*, Ge J*, Sun N*. Establishment of a PRKAG2 Cardiac Syndrome Disease Model and Mechanism Study Using Human Induced Pluripotent Stem Cells. J Mol Cell Cardiol. 2018, 13(117):49-61.
　　2.Li B, Yang H, Wang X, Zhan Y, Sheng W, Cai H, Xin H, Liang Q, Zhou P, Lu C, Qian R, Chen S, Yang P, Zhang J, Shou W, Huang G*, Liang P*, Sun N*. Engineering human ventricular heart muscles based on a highly efficient system for purification of human pluripotent stem cell-derived ventricular cardiomyocytes. Stem Cells Res Ther, 2017, 8(1):202.
　　3.Wang Q, Yang H, Bai A, Jiang W, Li X, Wang X, Mao Y, Lu C, Qian R, Guo F, Ding T, Chen H, Chen S, Zhang J, Liu C*, Sun N*. Functional engineered human cardiac patches prepared from nature's platform improve heart function after acute myocardial infarction. Biomaterials, 2016, 105: 52-65
　　4.Chao Lu, Yang Yang, Ran Zhao, Bingxuan Hua, Chen Xu, Zuoqin Yan, Ning Sun*, Ruizhe Qian*. Role of Circadian gene Clock during Differentiation of Mouse Pluripotent Stem Cells. Protein & Cell. 2016, 7:820-32. 共同通讯作者，封面文章(Cover Article)
　　5.Liang Q, Xu C, Chen X, Li X, Lu C, Zhou P, Yin L, Qian R, Chen S, Ling Z, Sun N*. The roles of Mesp family proteins: functional diversity and redundancy in differentiation of pluripotent stem cells and mammalian mesodermal development. Protein & Cell. 6:553-61,2015.
　　6.Zhao Q, Cai H, Zhan Y, Li B, Sun N*. Applications of Human Induced Pluripotent Stem Cells in the Investigation of Inherited Cardiomyopathy. Int J Cardiol. 15;177(2):604-6, 2014.
　　7.Sun N, Yazawa M, Liu J, Han L, Sanchez-Freire V, Abilez OJ, Navarrete EG, Hu S, Wang L, Lee A, Pavlovic A, Lin S, Chen R, Hajjar RJ, Snyder MP, Dolmetsch RE, Butte MJ, Ashley EA, Longaker MT, Robbins RC, Wu JC*. Patient-Specific Induced Pluripotent Stem Cell as A Model for Familial Dilated Cardiomyopathy. Science Translational Medicine. 4(130): 130ra47, 2012. 封面文章(Cover Article)
　　8.Liu J#, Sun N#, Bruce MA, Wu JC, Butte MJ*. Atomic Force Mechanobiology of Pluripotent Stem Cell-Derived Cardiomyocytes. Plos ONE. 7(5): e37559, 2012. #共同第一作者(Co-first Author)
　　9.Sun N, Longaker MT, Wu JC*. Human iPS Cell-Based Therapy: Considerations before clinical applications. Cell Cycle. 9(5): 1-6, 2010.
　　10.Sun N, T.W. Huiatt, Z. Li, D. Paulin, R.M. Robson*. Human synemin interacts with the LIM domain protein zyxin and is essential for cell adhesion and migration. Exp Cell Res. 316(3): 491-505, 2010. 重点突出文章(Highlighted Article)
　　11.Sun N, Lee A, Wu JC*. Long term non-invasive imaging of embryonic stem cells using reporter genes. Nature Protocols. 4(8): 1192-1201, 2009.
　　12.Sun N, Panetta NJ, Gupta DM, Wilson KD, Lee A, Jia F, Hu S, Cherry AM, Robbins RC, Longaker MT, Wu JC*. Feeder-free derivation of induced pluripotent stem cells from adult human adipose stem cells. Proc Natl Acad Sci U S A. 106(37): 15720-15725, 2009.
　　13.Sun N, Critchley DR, Li Z, Paulin D, Robson RM*. Human Alpha-Synemin Interacts Directly with Vinculin and Metavinculin. Biochem J. 409: 657-667, 2008. 获同行评价 (Editorial Commentury)
　　14.Sun N, Critchley DR, Li Z, Paulin D, Robson RM*. Identification of a Repeated Domain within Mammalian Alpha-Synemin that Interacts Directly with Talin. Exp Cell Res. 314: 1839-1849, 2008.
　　15.Zhu, Z., Hua, B., Shang, Z., Yuan, G., Xu, L., Li, E., Li, X., Sun, N., Yan, Z., Qian, R., and Lu, C. (2016) Altered Clock and Lipid Metabolism-Related Genes in Atherosclerotic Mice Kept with Abnormal Lighting Condition. BioMed research international 2016, 5438589
　　16.Zhu, Z., Hua, B., Xu, L., Yuan, G., Li, E., Li, X., Sun, N., Yan, Z., Lu, C., and Qian, R. (2016) CLOCK promotes 3T3-L1 cell proliferation via Wnt signaling. IUBMB life 68, 557-568
　　17.Song Y, Zhang C, Zhang J, Sun N, Huang K, Li H, Wang Z, Huang K, Wang L. An injectable silk sericin hydrogel promotes cardiac functional recovery after ischemic myocardial infarction. Acta Biomater. 2016, 41:210-23.
　　18.Jiang L, Yin M, Wei X, Liu J, Wang X, Niu C, Kang X, Xu J, Zhou Z, Sun S, Wang X, Zheng X, Duan S, Yao K, Qian R, Sun N, Chen A, Wang R, Zhang J, Chen S, Meng D. Bach1 Represses Wnt/β-Catenin Signaling and Angiogenesis. Circ Res. 117(4):364-75, 2015.
　　19.Wang L, Xu C, Zhu Y, Yu Y, Sun N, Zhang X, Feng K, Qin J. Human induced pluripotent stem cell-derived beating cardiac tissues on paper. Lab on a Chip. 15:4283-90, 2015.
　　20.Wang L, Chen B, Wang Y, Sun N, Lu C, Qian R, Hua L. hClock gene expression in human colorectal carcinoma. Mol Med Rep. 8(4):1017-22, 2013.
　　21.Gao Y, Meng D, Sun N, Zhu Z, Zhao R, Lu C, Chen S, Hua L, Qian R. Clock upregulates intercellular adhesion molecule-1 expression and promotes mononuclear cells adhesion to endothelial cells. Biochem Biophys Res Commun. 443(2):586-91, 2014.
　　22.Wang Y, Qian R, Sun N, Lu C, Chen Z, Hua L.Circadian gene hClock enhances proliferation and inhibits apoptosis of human colorectal carcinoma cells in vitro and in vivo. Mol Med Rep. 11(6):4204-10, 2015.
　　23.Narsinh HK, Sun N, Lee AS, Almeida P, Hu S, Jan T, Wilson KD, Leong D, Rosenberg J, Yao M, Wu JC*. Single cell transcriptional profiling reveals heterogeneity of human induced pluripotent stem cells. Journal of Clinical Investigation. 121(3): 1217-21, 2011.
　　24.Wilson KD, Sun N, Huang M, Zhang WY, Lee AS, Li Z, Wang SX, Wu JC*. Effects of ionization on self-renewal and pluripotency of human embryonic stem cells. Cancer Res. 70 (13): 5539-48, 2010.
　　25.Zhao H, Sun N, Young SR, Nolley R, Santos J, Wu JC, Peehl DM*. Induced pluripotency of human prostatic epithelial cells. PLoS One. 22;8(5):e64503, 2013.
　　26.Jia F, Wilson KD, Sun N, Gupta DM, Huang M, Li Z, Panetta NJ, Chen ZY, Robbins RC, Kay MA, Longaker MT, Wu JC*. A nonviral minicircle vector for deriving human iPS cells. Nature Methods. 7 (3): 197-9, 2010.
　　27.Wang Y, Zhang WY, Hu S, Lan F, Lee AS, Huber B, Lisowski L, Liang P, Huang M, de Almeida PE, Won JH, Sun N, Robbins RC, Kay MA, Urnov FD, Wu JC*. Genome Editing of Human Embryonic Stem Cells and Induced Pluripotent Stem Cells with Zinc Finger Nuclease for Cellular Imaging. Circ Res. 111:1494-1503, 2012.
　　28.Taylor RE, Kim K, Sun N, Park SJ, Sim JY, Fajardo G, Bernstein D, Wu JC, Pruitt BL*. Sacrificial layer technique for axial force post assay of immature cardiomyocytes. Biomedical Microdevices. 2012 Sep 25.
　　29.Levi B, Hyun JS, Montoro DT, Lo DD, Chan CK, Hu S, Sun N, Lee M, Grova M, Connolly AJ, Wu JC, Gurtner GC, Weissman IL, Wan DC, Longaker MT*. In vivo directed differentiation of pluripotent stem cells for skeletal regeneration. Proc. Natl. Acad. Sci. U.S.A. 109, 20379-84, 2012.
　　30.Pearl J, Leveson-Gower D, Lee A, Sun N, Negrin R, Wu JC*. Leukocyte Costimulatory Molecule Blockade Permits Allogeneic and Xenogeneic Engraftment of Pluripotent Stem Cells. Cell Stem Cell 8(3): 309-17, 2011.
　　31.Hammerick KE, Huang Z, Sun N, Lam MT, Prinz FB, Wu JC, Commons GW, Longaker MT*. Elastic Properties of Induced Pluripotent Stem Cells. Tissue Eng Part A. 17(3-4): 495-502, 2011.
　　32.Levi B, James AW, Nelson ER, Hu S, Sun N, Peng M, Wu J, Longaker MT*. Studies in adipose-derived stromal cells: migration and participation in repair of cranial injury after systemic injection. Plast Reconstr Surg. 127 (3): 1130-40, 2011.
　　33.Hu S, Huang M, Li Z, Jia F, Ghosh Z, Lijkwan MA, Fasanaro P, Sun N, Wang X, Martelli F, Robbins RC, Wu JC*. MicroRNA-210 as a Novel Therapy for Treatment of Ischemic Heart Disease. Circulation 122: S124-31, 2010.
　　34.Wilson KD, Hu S, Venkatasubrahmanyam S, Fu JD, Sun N, Abilez OJ, Baugh JJ, Jia F, Ghosh Z, Li RA, Butte AJ, Wu JC*. Dynamic MicroRNA Expression Programs during Cardiac Differentiation of Human Embryonic Stem Cells: Role for miR-499. Circ Cardiovasc Genet. 3(5): 426-35, 2010.
　　35.Chen MQ, Xie X, Wilson KD, Sun N, Giovangrandi L, Wu JC, Kovacs GT*. Current-controlled electrical point-source stimulation of embryonic stem cells. Cellular and Molecular Bioengineering. 2009; 2(4) 625-635, 2009.
　　36.Wilson KD, Venkatasubrahmanyam S, Jia F, Sun N, Butte AJ, Wu JC*. MicroRNA profiling of human-induced pluripotent stem cells. Stem Cells and Development. 18(5): 749-58, 2009.
　　37.盐酸克伦特罗对人类诱导多能干细胞来源心肌细胞的毒性作用。杨慧;吴劭一;毛益申;王青洁;刘琛;周奕;孙宁。 《微循环学杂志》, 04：15-86, 2015.
　　学术专著
　　申请或授权专利
　　授权专利
　　申请专利
　　1.Cardiomyocytes From Induced Pluripotent Stem Cells From Patients and Methods of Use Thereof ，美国，61/510422
　　2.Enhanced Efficiency of Induced Pluripotent Stem Cell Generation，美国，12/931476
　　3.一种组织工程化人类心肌组织，中国，201510198437.5
　　4.多能干细胞-遗传性心肌病心肌细胞及其制备方法 ，中国，201510198437.5