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姓名：陆路 博士
职称：研究员
E-MAIL: lul@fudan.edu.cn
研究方向
1.多肽和抗体等蛋白类抗病毒药物的研究
2.新发突发病毒感染防治策略的研究
3.具有生物功能的创新蛋白的研究及应用
重要学术贡献
(1)聚焦于研究抗病毒“蛋白类灭活剂”的基础理论，并以HIV、ZIKV等病毒为模式生物深入揭示该新型蛋白药物的设计规律及独特机理，丰富了病毒入侵抑制剂的研究领域;
(2)完善了研究I型包膜病毒膜融合机制和相关抑制剂的系统技术体系，并利用该体系揭示中东呼吸系统综合症冠状病毒的入侵靶细胞的关键蛋白质机器—融合活性六螺旋特征，并设计研究了针对该靶点的多肽类入侵抑制剂;
(3)实践转化医学，多项专利成功转让及转化，形成产品上市销售。
荣誉与获奖
国内外学术团体任职
2016-2021 中国微生物学会人兽共患病病原学专业委员会委员
2015-2021 中国微生物学会医学微生物学与免疫学专委会青年委员会副主任委员
2015-2021 中华医学会微生物与免疫专业委员会青年委员
2013-2017 中国微生物学会病毒学专业委员会青年委员
2017-今 上海市医学会医学病毒专科分会青年委员
受邀审稿学术刊物
1.AIDS, ad hoc Reviewer
2.Scientific Reports, ad hoc Reviewer
3.Journal of Virology, ad hoc Reviewer
4.Plos One, ad hoc Reviewer
5.Journal of Biochemistry, ad hoc Reviewer
6.Antiviral therapy, ad hoc Reviewer
7.Virology, ad hoc Reviewer
校内学术机构任职
受邀学术报告
发表论文
1.Yu, Y. #, Deng, Y. #, Zou, P. #, Wang, Q., Dai, Y., Yu, F., Du, L., Zhang, N., Tian, M., Hao, J., Meng, Y., Li, Y., Zhou, X., Chan, JF., Yuen, KY., Qin, CF*., Jiang, S*, Lu, L*. A peptide-based viral inactivator inhibits Zika virus infection in pregnant mice and fetuses. Nat. Commun. 2017. Jul 25;8:15672
2.Wang, Q., Dai, Y., Sun, Z., Su, X., Yu, Y., Hua, C., Xu, W., Jiang, S*, Lu, L*. HIV-1 Env DNA prime plus gp120 and gp70-V1V2 boosts induce high level of V1V2-specific IgG and ADCC responses and low level of Env-specific IgA response: implication for improving RV144 vaccine regimen. Emerg. Microb. Infect. 2017, 6, e102
3.Cui, L. #, Zou, P. #, Chen, E. #, Yao, H., Zheng, H., Wang, Q., Zhu, JN., Jiang, S*, Lu, L*., Zhang, J*. Visual and Motor Deficits in Grown-up Mice with Congenital Zika Virus Infection. EbioMedicine. 2017 Jun;20:193-201
4.Qi, Q. #, Wang, Q. #, Chen, W., Du, L., Dimitrov, D., Lu L*., Jiang, S*. HIV-1 gp41-targeting fusion inhibitory peptides enhance the gp120-targeting protein-mediated inactivation of HIV-1 virions. Emerg. Microb. Infect. 2017 Jun 21;6(6):e59.
5.Tan, Y., Wang, J., Su, S., Wang, Q., Jiang, S., Lu, L.*, Chen, Y.* Enhancement of endocytic uptake of HIV-1 virions into CD4-negative epithelial cells by HIV-1 gp41 via its interaction with POB1. Cellular & Molecular Immunology. 2017 Jun;14(6):568-571.
6.Su, S#., Wang, Q#., Xu, W., Yu, F., Hua, C., Zhu, Y.,*., Jiang, S*, Lu, L*. A novel HIV-1 gp41 tripartite model for rational design of HIV-1 fusion inhibitors with improved antiviral activity. AIDS. 2017 Apr 24;31(7):885-894.
7.Li, H., Yu, F., Xia, S., Yu, Y., Wang, Q., Lv, M., Wang, Y., Jiang, S*, Lu, L*. Chemically Modified Human Serum Albumin Potently Blocks Entry of Ebola Pseudoviruses and Viruslike Particles. Antimicrob. Agents Chemother. 2017 Mar 24;61(4).
8.Lu, L. *, Zhu, Y., Jiang, S. Is α4β7 a hiding target for HIV vaccines? Science. 2016, http://science.sciencemag.org/content/354/6309/197/tab-e-letters
9.Su, S. #, Zhu, Y. #, Ye, S. #, Qi, Q., Xia, S., Yu, F., Wang, Q., Zhang, R*., Jiang, S*, Lu, L*. Creating an artificial tail anchor as a novel strategy to enhance the potency of peptide-based HIV fusion inhibitors. J. Virol. 2016 Dec 16;91(1)
10.Sun, Z. #, Zhu, Y. #, Wang, Q#., Ye, L., Dai, Y., Su, S., Yu, F., Ying, T., Yang, C., Jiang, S*, Lu, L*. An immunogen containing four tandem 10E8 epitope repeats with exposed key residues induced antibodies to neutralize HIV-1 and to activate ADCC reporter gene. Emerg. Microb. Infect. 2016. 5(6):e65 |
发表于 2018-6-8 21:45:42