复旦大学基础医学院研究生导师简介-陈舌教授

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　　姓名：陈舌 博士
　　职称：研究员
　　E-MAIL: shechen@fudan.edu.cn
　　WWW: http://www.------
　　研究方向
　　1.细胞极性与肿瘤
　　2.代谢性疾病
　　3.神经发育
　　重要学术贡献
　　主要从事肿瘤、代谢性疾病及神经发育领域基础研究，发现了mPar3调节神经细胞极性形成的分子机制;FXR调节肝脏代谢、脂肪肝及肝癌发生发展的分子机制;TLR2抑制肝纤维化的分子机制;I1PP2A 和I2PP2A在阿尔茨海默病(AD)中对蛋白磷酸酶PP2A调节机理等研究成果。共发表SCI论文30余篇，其中通讯作者及第一作者文章17篇，论文被他引550余次，相关研究成果发表在Developmental Cell、Science及Nature等国际顶 尖期刊上。
　　国内外学术团体任职
　　2017-今 上海市细胞生物学会理事
　　受邀学术报告
　　1.2015 Farnesoid X Receptor associates with -catenin and inhibits its activity in hepatocellular carcinoma 乳腺癌多学科合作论 坛(上海)
　　2.2015 神经发育的分子调控机制─mPar3, Dasm1, APC. 国际成体神经干细胞与神经退行性疾病研讨会_2015(北京)
　　3.2015 IgSF protein Dasm1 in Dendrite Development. 第一届中德脑神经研讨会(北京)
　　4.2015 Farnesoid X Receptor (FXR) in Liver Disease. 第六届国际基因产业大会(青岛)
　　5.2017 VEPH1 antagonizes mTOR signaling pathway through enhancing TSC1/TSC2 interaction in HCC. 华东六省一市生物化学与分子生物学学会2017年学术交流会(合肥)
　　6.
　　代表性论文：
　　1.Dong P, Ma L, Liu L, Zhao G, Zhang S, Dong L, Xue R, Chen S*. CD86+/CD206+, Diametrically Polarized Tumor-Associated Macrophages, Predict Hepatocellular Carcinoma Patient Prognosis Int. J. Mol. Sci. 2016, 17(3), 320.
　　2.Wang B, Yang Z, Wang H, Cao Z, Zhao Y, Gong C, Ma L, Wang X, Hu X, Chen S*. MicroRNA-320a inhibits proliferation and invasion of breast cancer cells by targeting RAB11A. Am J Cancer Res. 2015 Aug 15;5(9):2719-29.
　　3.Liu X, Zhang XW, Ji LL, Gu JX, Zhou ML, Chen S*. Farnesoid X Receptor associates with b-catenin and inhibits its activity in hepatocellular carcinoma. Oncotarget. 2015;6(6):4226-38
　　4.Ji L, Xue R, Tang W, Wu W, Hu T, Liu X, Peng X, Gu J, Chen S*, Zhang S*. Toll like receptor 2 knock-out attenuates carbon tetrachloride (CCl4)-induced liver fibrosis by downregulating MAP K and NF-κB signaling pathways. FEBS Lett. 2014; 588 (12): 2095-2100
　　5.Liu X, Xue R, Ji L, Zhang X, Wu J, Gu J, Zhou M, Chen S*. Activation of farnesoid X receptor (FXR) protects against fructose-induced liver steatosis via inflammatory inhibition and ADRP reduction. Biochem Biophys Res Commun. 2014; 450 (1): 117-123
　　6.Chen S*, Chen J, Shi H, Wei M, Castaneda-Castellanos DR, Bultje RS,Pei X, Kriegstein AR, Zhang MJ and Shi SH*. Regulation of microtubule stability and organization by mammalian Par3 in specifying neuronal polarity. Dev Cell 2013;24(1):26-40 (* 并列通讯) (封面文章)
　　7.Yu YC*, He SJ*, Chen S, Fu YH, Brown K, Yao XH, Ma J, Gao P, Sosinsky G, Huang K and Shi SH. Preferential electrical coupling regulates lineage-dependent microcircuit assembly in the neocortex. Nature 2012; 2;486(7401):113-7.
　　8.Brown K, Chen S, Han Z, Lu CH, Tan X, Ding L, Zhang XJ, Cruz A, Saur D, Anderson S, Huang K, and Shi SH. Clonal Production and Organization of Inhibitory Interneurons in the Neocortex. Science. 2011; 334(6055):480-6.
　　9.Chen S, Li B, Grundke-Iqbal I, Iqbal K. I1PP2A affects tau phosphorylation via association with the catalytic subunit of protein phosphatase 2A. J Biol Chem. 2008 Apr 18;283(16):10513-21
　　10.Chen S, Yin X, Zhu X, Yan J, Ji S, Chen C, Cai M, Zhang S, Zong H, Hu Y, Yuan Z, Shen Z, Gu J. The C-terminal kinase domain of the p34cdc2-related PITSLRE protein kinase (p110C) associates with p21-activated kinase 1 and inhibits its activity during anoikis. J Biol Chem. 2003;278(22):20029-36.